Cameron postpones her vacation with Chase to take on the case of an environmentalist who collapsed in the middle of a protest. Meanwhile, House wonders why Wilson is starting a new healthy diet.

While House tries to cope with his insomnia, he takes on the case of a ballerina whose skin begins to fall off after treatment following the collapse of her lungs during a rehearsal.

House takes on a case of a patient with two different personalities as a result of having the left and right part of the brain operating independently. Meanwhile, he deals with the aftermath of his night of sex with Cuddy.

A deaf 14-year old wrestler suffers from hearing problems during a match, but his mother refuses to okay cochlear implants. Meanwhile, House’s insomnia proves a curse… and a blessing.

The team deals with an older woman who has been tending to her dying husband but is stricken down with an unknown disease that threatens to kill her before her husband. However, they must overcome their own emotions when a tragedy strikes one of their members.

A patient with both male and female DNA has the team stumped. Meanwhile, House starts acting nicely, raising Cuddy’s and Wilson’s suspicions that something is terribly wrong.

House struggles with his own beliefs as he takes on a case of priest with a disturbing past who runs a shelter for homeless people and sees a vision of Jesus.

The team take on the case of a Special Education teacher who spits up blood and collapses in the middle of class. Meanwhile, Cameron finds herself taking on some of Cuddy’s duties, including dealing with House, and Foreman has to make a decision concerning Thirteen’s participation in the clinical trials.

House is injured in a motorcycle accident in New York and finds himself in bed next to a patient suffering from complete paralysis. As House transfers the patient to Princeton to determine what’s wrong with him, Wilson tries to find out why House was in New York.

A nursing home worker, Morgan, fakes an illness to get House to examine a cat which can predict the death of elderly patients. House doesn’t believe it… until Morgan becomes ill for real.